Sentence examples for deleterious rise from inspiring English sources

Such a deleterious rise in NO resulted essentially from the enhanced iNOS activity in neurons, astrocytes and microglial cells.

The available evidence suggests that increased K+ intake might reduce BP or at least prevent a deleterious rise in BP with age [ 36].

For example, if declining GFR in hyperfiltering subjects is also associated with a deleterious rise in arterial stiffness, this could yield important pathophysiologic insights into mechanisms of disease progression and clinical prognostic information (1, 7).

Their consequences are usually deleterious, giving rise to individuals who are unhealthy or sterile, though in rare cases alterations provide new adaptive opportunities that allow evolutionary change to occur.

If weakly deleterious mutations rise to prevalence via the positive selection of separate fitness increasing traits, we expect to find positive selection within relatively weakly deleterious mutations.

These sweeps would have allowed neutral and mildly deleterious alleles to rise in frequency and fix in the genome through genetic hitchhiking.

Thus, the only new strongly deleterious mutations that rise to ultimate fixation are those exceptionally rare mutants that rapidly and continually increase stochastically in frequency faster than the mutant alleles can be purged from the population by purifying selection.

At any rate, even if inactivation of a fair portion of genes leads to co-recessive phenotypes through an effect of gene dosage, the frequency of deleterious mutations giving rise to completely recessive phenotypes will still be much higher than those leading to dominant, or co-dominant traits.

First, the absolute upper bound for atmospheric CO2 stabilization is higher than the 450 500 ppm range recommended to avoid deleterious effects of rising surface ocean pCO2 on reef accretion [4], [41].

Deleterious effects of rising temperature on aerobic performance has already led to population collapses and ecosystem shifts in polar and temperate regions [9], and similar effects might be expected to occur in tropical marine systems.

A precise calculation of extinction time in this model would require the integration of the effects of increasing mutation accumulation over time, where the increase is caused by rising deleterious mutation rates due to the progressive inactivation of genes.