Sentence examples for deleterious rate from inspiring English sources

Such mechanisms are routinely supported by site-directed mutagenesis experiments in which large deleterious rate effects are observed when putative catalytic residues are mutated.

Within the set of deleterious mutations there are n classes according to their effect size: those with deleterious effect s i arise at genomic rate U i. The combined deleterious rate across all mutations is ∑ i U i = U.

A role for Pro39 in positioning the general base was suggested previously by Choi et al. on the basis of the deleterious rate effects from mutations of Pro39 to alanine or glycine, as well as a crystal structure of the P39A mutant that showed the general base carboxylate displaced by ∼3 Å relative to the WT.

Similarly, it would be possible to distinguish between simple clonal turnover and clonal decay if realistic estimates of relevant parameters such as the deleterious mutation rate or rate of clonal recruitment were available.

Partitioning the deleterious mutation rate U into a lethal rate (UL) and a nonlethal rate (UnL), Equation 1b may be rewritten as W ¯ ∞ = (W 0   e − U L ) ⋅ e − U nL.

We considered a haploid population of Y chromosomes evolving under the Wright Fisher model, and introduced a Y variant to study its fate through Monte Carlo simulations with varying population genetics parameters (e.g., population size, deleterious mutation rate, and gene conversion rate).

Letting U be the genome-wide deleterious mutation rate in the MM background, deleterious mutations arise at rate U + Δ U within Mm individuals, and we assume that each mutation arises at a unique site (ensuring that all mutations remain heterozygous in a diploid species).

This list includes the unlikely possibility that the true deleterious mutation rate might be much lower, either because mutation rates in the Amazon molly happen to be generally much lower for yet unknown reasons, or because the distribution of mutational effects happens to be strongly bimodal with almost no mutations in the critical intermediate range.

I would like to see the per-genome deleterious mutation rate U. Author's response: The effect of deleterious mutation rate is now demonstrated on Figure 3a.

Given that the deleterious mutation rate λ is likely to decrease with the overall mutation rate, we would expect influenza B to carry a lower mean mutation load and further to have lower fitness variance.

Genomic deleterious mutation rate of females was 0.3 per generation whereas the male mutation rate was varied between 0.3, 0.6, 1.8 and 3.0 corresponding to α = 1, 2, 6 and 10.