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These tools used in sync can provide valuable information when the deleterious potential of a mutation is otherwise difficult to assess.
Achieving this for genetic changes requires functional separation of the genome into readily changing elements with relatively low deleterious potential and rarely changing elements with high deleterious potential.
Fig. 1 Putative distribution of (trait) flexibility and deleterious potential (risk level).
The usefulness of this restriction depends, however, on the ability to differentially suppress changes in loci with high deleterious potential.
This requires a strong inverse correlation between the flexibility of traits and their deleterious potential (Fig. 1).
As previously suggested (Kumar et al. 2009), SIFT pathogenicity scores ≤ 0.05 were considered as having the highest deleterious potential.
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The recently published article by Fugate et al. [ 1] reminds us of the frequently underappreciated yet deleterious neurotoxic potential of cefepime (CEF) in critically ill patients with pre-existent or acute kidney dysfunction [ 2].
Although they have been widely demonstrated [5], the potential deleterious effects of CB were not modelled.
However, in this study, hypothermia lasted only 2 hours, and potential deleterious effect could be observed.
Ecologists have opposed the site because of potential deleterious effects on local elephant populations.
However, the potential deleterious effects resulting from the replacement of the traditional treatments was not considered.
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