Histologic chorioamnionitis (HCA) is commonly associated with preterm birth and deleterious post-natal outcomes including sepsis and necrotizing enterocolitis.
By virtue of its interaction with the N17 domain, TRiC might provide a protective effect against deleterious post-translational modifications.
Having ruled out mitochondrial biogenesis as a potential mechanism underlying the effects of EPA on mitochondrial function, we discovered that EPA reduced deleterious post-translational modifications, most notably carbamylation of mitochondrial proteins.
For example, in children, pre-natal exposure may be more deleterious than post-natal exposure for most, but likely not all, neuro-developmental measures (Myers et al. 2009; Saint-Amour et al. 2006).
Morbid effects of shivering include an increase in myocardial oxygen consumption, lactic acidosis, and a resistance to cooling, all of which can be deleterious in the post cardiac arrest patient [ 22].
They also underscore the importance of prevention efforts designed to mitigate the deleterious effects of post-disaster stressors, most notably financial distress, in older persons affected by disasters.
Angelos et al. demonstrated a deleterious effect of post-ROSC hyperoxemia on a rat model.
Comparisons to other species would enable to disentangle the effect of relaxation of natural selection due to technological, cultural and anatomical innovations of modern humans from other factors slowing down the purification of DNA from slightly deleterious mutations, such as post-glacial population growth.
In conclusion, this study confirming the possibility that vitamin C counterbalances the deleterious effects of hyperglycemia post-hypoglycemia underlines the role of the oxidative stress in this phenomenon.
On the other hand, this may be deleterious in tissues with post-mitotic cell populations, such as heart and the central nervous system [ 40, 41], where results generated from invertebrate models are more likely to be applicable in direct fashion, such that manipulations augmenting HSP activity might positively affect lifespan or certain disease outcomes.
Reporting outcomes that were radiological (fracture reduction, union, subsequent OA) or clinical (functional scores, patient-reported outcomes, need for subsequent operation including arthroplasty), and/or post-operative complications (defined as any deleterious event described by study authors as post-operative complications).
