Lynch, M, Blanchard, J, Houle, D, Kibota, T, Schultz, S, Vassilieva, L, and Willis, J. "Perspective: Spontaneous deleterious mutation". Evolution 53, no. 3 (June 1 , 1999: 645-663.
Although CNV deletions may constitute a major form of deleterious variants, this theoretical perspective also expects that some mutations at the single nucleoside level affect intelligence as well.
Using this approach, a list of potentially deleterious variants from a structural perspective can be generated rapidly, providing a way to integrate structural analysis into the variant categorization scheme.
Obviously, the major concerns of weight cycling deleterious effects in a public health perspective remain in a possible fat mass increase [ 3] or in a decrease in resting metabolic rate [ 12].
Therapeutic control of platelet functions would offer the perspective of targeting simultaneously several deleterious pathways in sepsis.
Platelet activation can drive multiple inflammatory and coagulation pathways, and targeting platelets offer the theoretical perspective of targeting simultaneously several deleterious pathways.
Considering these findings in the light of the evolutionary theory of ageing and longevity, particularly as regards the 'mutation accumulation' of late acting deleterious alleles, we can identify an important perspective on this concept.
I thus contend that the concept of "mildly deleterious mutations" derived from a very anthropocentric perspective of well fed, wealthy, healthy and secure people.
We compile and summarize the spectrum of published variants analyzed by IT, to provide a broad perspective of the distribution of deleterious natural and cryptic splice site variants detected, as well as those affecting splicing regulatory sequences.
While the chronic use of vitamin C cannot be the solution (28), recent development in the antioxidant treatment of diabetes-related complications might provide a future perspective also in preventing the deleterious effects of hypoglycemia on the cardiovascular system (29).
From a Constitutional perspective, the Court decided Citizens United v. Federal Elections Commission correctly in my view, despite the clearly deleterious consequences to our society.
