Although some of the personal exposure away from home also occurred in indoor setting, the significant inverse association with MVF may support the notion of deleterious effect of traffic- and diesel engine-generated particles on endothelial function found in a number of studies with controlled exposure at high levels [ 21, 22].
RNA recombination creates advantageous genotypes by evolutionary jumps [ 30], which permits the removal of deleterious genes based on the notion of "Muller's ratchet" from the host cell, usually mammalian cells [ 12].
Notably, neo-Y chromosomes have the highest proportion of tandem duplicates overlapping with coding regions, supporting the notion that slightly deleterious effects of extra gene or exon doses associated with these tandem duplications are not being effectively purged from the neo-Y.
The notion that competition has deleterious effects is nothing new.
Support for this notion is provided by studies demonstrating deleterious effects of general anaesthesia on cognitive function in patients after surgery and from in vitro studies attributing neurotoxicity to anaesthetics.
Indeed, growing data support the notion that lactate production is not deleterious, but rather is an adaptative response allowing one to maintain an appropriate energetic metabolism in the case of shock or organ failure [ 2- 4].
The fact that CAG0 and CAG23 mice, which expressed high levels of EGFP protein, lacked a discernable phenotype further supports the notion that expanded CAG repeat RNA is deleterious.
Combined with the lack of effects on cell metabolism, this data supports the notion that DS-SILY20 does not have deleterious effects on normal cell behavior, but suppresses behavior that leads to intimal thickening in proliferative SMCs.
Much has been said about this notion of "uncertainty" being a new, super-deleterious thing for the economy, but I think Barry Ritholtz said it best: "Kiss your assets goodbye when certainty reigns".
These data support the notion that expanded CAG repeat RNA can cause deleterious effects in mammals.
