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According to SIFT analysis, these mutations should not affect the protein function in a deleterious manner.
This suggests that Nrf2 can also act in a deleterious manner in the context of systemic bacterial infections.
In light of this confounding paradox, we will examine the factors and circumstances that determine whether H2O2 acts in a pro-survival or deleterious manner.
However, it is reasonable to imagine that one or more of these proteins, if produced, may differentially associate with the paternal chromatin in some deleterious manner.
2 When these cells are chronically present in excess however, they may indeed participate in a deleterious manner towards organ dysfunction.
Furthermore, continuation of an avoidance response contributes to the pain experience in a deleterious manner by making it more likely to maintain high levels of pain-related fear and pain catastrophizing.
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"I find particularly deleterious this manner of hunting in a pack, as a clan, to impress and pressure," Mr. Assouline told Agence France-Presse.
The atherosclerotic plaque, a nonresolving inflammatory site, comprises a complex scenario of monocyte recruitment, overwhelmed capacity for phagocytic removal of lipid-laden apoptotic ('foam') cells coupled with further cell death and further recruitment in a progressive and deleterious pathological manner.
We suggest that the conjugation of reactive electrophiles which are formed in an uncontrolled manner are deleterious to endogenous low-level signalling, and the GSH systems 'insulate' against high levels of electrophile production which may cause cellular damage.
Such trapped objects can then be subjected to spectroscopic investigation [4] [22] in such manner that the deleterious effects on spectral quality of the inevitable Brownian motion are circumvented.
These findings provide independent confirmation that TCE exposure alters heart development in a manner that has deleterious, functional consequences.
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