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The proportion is further elevated at deleterious loci for both population models.
Sites with DAC > 10 represent between 0% and 3.3 × 10−5% of the lost sites at deleterious loci for the model without and with growth, respectively.
As expected, the average number of mutations per chromosome, L, is much larger at the neutral loci than at the deleterious loci.
In contrast to the increase of % Slost when considered across all DACs, we observe that within each DAC category, population growth decreases % Slost, both for neutral (36.7% to ∼30.4%) and for deleterious loci (∼44.1% to ∼39.7% for singletons).
BDM incompatibilities will, however, also arise within species (see Cutter 2012 for review) and theoretical analyses suggest that interactions between synthetic deleterious loci are common (Phillips and Johnson 1998; Lachance et al. 2011).
The aim of the current study was to (1) carry out a genome-wide scan for deleterious mutations in a maize diversity panel, (2) analyze their distribution across the genome and within different genetic groups, and (3) test for enrichment of deleterious loci in the results of genome-wide association mapping.
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The three loci are not linked, though, suggesting that if the distortion observed has a genetic basis, it is not caused by just one deleterious locus in the genome.
This increase in L is steady over the generations of population growth, but in stark contrast to the several orders of magnitude increase of S, L increases by only 0.9% relative to the model without growth at the neutral locus, and by only 6% at the deleterious locus.
These findings suggest that our Genets differed in the number and type of deleterious recessives/overdominant loci that affect reproductive output.
Differences between the respective nLTR-RT landscapes of the vertebrate lineages may be due to differences in the strength of purifying selection against deleterious element-containing loci in populations (Charlesworth B and Charlesworth D 1983; Charlesworth et al. 1994; Le Rouzic and Deceliere 2005).
Our framework assumes only modest benefits per regulatory locus for adaptive interactions and identical deleterious costs per locus for maladaptive binding events.
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