Sentence examples for deleterious load from inspiring English sources

Individuals were then scored according to the sum of the predicted deleterious load contributed by their nsSNPs.

When only the weak criterion is satisfied, the population may expand hundreds of generations before the deleterious load is expected to halt growth (Bull and Wilke 2008).

One possible explanation for low genomic mutations rates in bacteria is that mutator hitchhiking is inhibited in haploid bacterial populations by the associated deleterious load.

In their model, schizophrenia represents the negative, maladaptive extreme of a sexually selected fitness indicator, that is, a trait (or suite of correlated traits) that reveals to potential mates an individual's underlying genetic quality (e.g., low deleterious mutation load) and condition (e.g., good nutritional status, low pathogen load).

Returning to our model, given that an antigenic mutation arises in a strain carrying some deleterious mutation load, one might expect the virus population's deleterious mutation load to increase in the long run, causing a long-term decline in influenza A/H3N2 fitness.

The relative rate of antigenic evolution is given by the fraction of arising antigenic mutants that establish under the deleterious mutation load relative to the fraction of arising antigenic mutants that would establish under a no-load scenario.

Recent phylogenetic analyses indicate that RNA virus populations carry a significant deleterious mutation load.

The effect of a deleterious mutation load on the fate of an antigenic mutant.

10.7554/eLife.07361.010 Figure 8. Simulations of the phylodynamic model in the absence of a deleterious mutation load.

In comparison, non-synonymous polymorphisms show a much greater proportion of singletons, 81.6%, consistent with a slightly deleterious genetic load.

Provided |Δ U|≫2μ, both mutators and antimutators are potentially driven by indirect selection on the associated deleterious mutation load.