In contrast to more deleterious levels of peroxide exposure (≥0.1 M), CMP did not significantly affect membrane electrophysiological parameters or responses to excitatory amino acids.
Intravitreal implantation of encapsulated factor secreting cells has the disadvantage of non-specific exposure of intraocular structures to potentially deleterious levels of growth factor, and there is limitation of allowing repeat implantation, which is required to sustain long-term efficacy.
On the other hand, reward responses are believed to buffer otherwise deleterious levels of heightened anxiety and stress [ 30].
Ever-drinking was associated with deleterious levels of four of the six aforementioned predictors, except age and adjuvant treatment.
Thus, increased visceral fat increases delivery of deleterious levels of FFA to the liver via the portal vein, leading to elevated hepatic triglyceride concentration and hepatic insulin resistance.
Arguably and alarmingly our data suggest that the strong correlation we have identified between ambient levels of air pollutants and spontaneous abortion in UB may also obtain elsewhere in the world, where similarly deleterious levels of air pollution exist.
We identify a DBP of <70 mmHg as the cutoff for deleterious levels of DBP and a DBP <60 mmHg as a likely cutoff associated with even greater significant risks for CVD events.
Without such Ca2+ entry, continued activation of the plasma membrane Ca2+-adenosine triphosphatase pump upon secretagogue- or toxin-mediated release of Ca2+ from intracellular stores could deplete these stores to deleterious levels, inducing or exacerbating endoplasmic reticulum stress.
Since the genes encoding CNGC19 and CNGC20 are upregulated by salt stress (Maathuis, 2006; Kugler et al. 2009; Yuen and Christopher 2010), one possible function of these channel proteins is to ameliorate the effects of deleterious levels of Na+ in the cytosol by facilitating Na+ redistribution between the cytosol and vacuole.
Direct tests of genetic adaptation are very effective in establishing a concrete, and potentially deleterious population-level effect of contaminant exposure, but they are difficult to accomplish with most field-exposed organisms.
