Sentence examples for deleterious imbalance from inspiring English sources

Cerebral rStO2 monitoring and a dedicated treatment guideline 18 are the cornerstones of a brain oriented protection strategy, with the goal of reducing periods of deleterious imbalance between oxygen delivery and consumption.

We show that infection with A (H1N1 pdm09 was accompanied by changes in peripheral blood lymphocyte subgroups and cytokine profiles, leading to deleterious imbalances in innate and adaptive immunity.

The comprehension of the nucleotide sequences leading to genomic instability might ultimately lead to understand whether deleterious imbalances, both constitutional and acquired, occur at random in people sharing apparently identical genome sequences at a certain locus or are linked to specific haplotypes.

The balance between pro- and anti-inflammatory immune cell phenotypes may be modulated to avoid the deleterious immune imbalance that provokes metabolic alterations in pregnancies complicated by obesity.

Immediately after a WGD event, genome-wide relative gene dosage is maintained, but subsequent step-wise mutation or deletion of duplicated genes can lead to deleterious dosage imbalances.

Perhaps, the levels of compensation are determined by the selection against deleterious effects of imbalance, where higher compensation would have evolved for more deleterious dose changes in these cells.

It appears that these two classes of proteins are exceptional: the former are subunits of stoichiometric complexes whose duplications is discourage by selection due to the deleterious effects of imbalance [ 26], whereas the former are adaptive linear specific expansions of paralogous families evolving under positive selection [ 30].

A heterozygous duplication (an extra copy of some chromosome region) also results in a genomic imbalance with deleterious consequences.

Obesity and the overproduction of inflammatory cytokines have been implicated in the induction of numerous pathogenic mechanisms that can be responsible for autonomic imbalance impacting deleterious processes that increase and perpetuate cardiovascular risk.

Kirkpatrick and Barton's theory was a significant advance in our expectations for the evolutionary dynamics of inversions, which previously assumed that they would be generally deleterious due to meiotic imbalance or disrupted genes at the breakpoints (Kirkpatrick 2010).

Moreover, the imbalance in deleterious and protective adipokines including adiponectin and resistin plays pivotal roles in the development and progression of pancreatic beta-cell dysfunction under insulin-resistant conditions [ 75].