With SIFT, we set up three rMS grades: (1) the program's standard likely neutral grade of SIFT score >0.05, (2) a likely deleterious grade of 0.05 ≥ SIFT score ≥ 0.01, and (3) a more likely deleterious grade of SIFT score 0.00.
For the two participants who carried more than one rare variant of interest (one participant carried p.I448S (C15) plus p.E394D (C35), and one participant carried p.E239K (C15) plus p.R346H (C25)), only the variant belonging to the more likely evolutionarily deleterious grade (that is, higher C-number as scored by Align-GVGD) was considered.
"That stands in stark contrast to 100 years of research that shows the ineffective and often deleterious outcomes associated with grade retention".
We played the word game hangman in class most days – all with movie titles – which had a deleterious effect on my grades, but not Mike's.
Aside from satisfying political needs, inflated grades have a very deleterious effect on students by ultimately determining incorrect placement in future courses through a faulty assessment of their skills.
Old age, worse performance status, WHO grade IV and tumor recurrence had deleterious effects on HRQOL.
After thorough debridement of all devitalized tissues, irrigation of the wound should be carried out with caution as this may also have deleterious effects on bone and healthy soft tissue (Grade C).
For mines producing thermal coals, keeping rank and grade to specification is the prime task, along with tracking deleterious trace elements in product and reject.
Diet composition may strongly influence changes in the microbiota, which in turn, when subjected to deleterious nutritional environment, might affect intestinal permeability and result in low-grade inflammation, obesity, and associated chronic metabolic diseases such as NAFLD, dyslipidaemia, and insulin resistance [ 9, 32].
In spite of the frequent shift from a low-risk to a high-risk classification on final pathology, avoiding lymphadenectomy in low-grade endometrial cancer has been shown to have no deleterious impact on overall or disease-free survival (Benedetti Panici et al, 2008; Bernardini et al, 2009; Neubauer et al, 2009).
Adenomas, fibroadenomas,and carcinomas were deleterious to health due to their very large size(Figure 5A,B,C) rather than the grade of the tumoritself.
