This illustrates that the use of TGF-β for cartilage repair can result in side effects that are deleterious for future therapeutic applications.
Our results suggest that the influence of early-onset obesity (before 16 years of age) may be particularly deleterious for future diabetes risk for women and could potentially be related to biological factors associated with being obese during pubertal maturation.
Another counterargument is that informing large numbers of people that deception has been used may have deleterious impacts on future participation in research, thus diminishing the methodological rigor and hence the social value of future research.
Instead, the U.S. initially claimed that revealing these materials as part of a lawsuit against the government would have a deleterious effect on future inquiries into aviation safety because, in the absence of confidentiality, witnesses and investigators would pull their punches.
In a few families, mutations undetectable by the techniques used may be present (e.g. regulatory mutations) or some of the genetic variants reported as being of 'uncertain significance' may be characterised as deleterious in the future.
When a UV is identified, women are told that this result does not allow for concluding that a causal mutation was found; however, clinicians will be kept informed whether this mutation is reclassified as deleterious in the future.
These data argue that pharmacological inhibition of IL-4Rα signalling, currently being developed for treatment of asthma and inflammatory bowel disease (28, 29), could have deleterious consequences for future 'sporadic' CRC risk and any therapy involving IL-4R antagonism requires careful long-term evaluation in order to monitor colorectal adenoma and CRC risk.
6 While it is clear that adequate access to emergency operative delivery can save the life of both the mother and infant, 7 8 high rates (particularly rates above 15%) have not been shown to improve pregnancy outcomes, and may have a deleterious effect on future pregnancies.
Therefore, some of these may be classified in the future as deleterious, and accordingly, our estimated frequency of deleterious mutation presented here is likely to be an underestimate.
