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The point of describing an outcome as harmful, it has been thought by many, is to say that 'it is deleterious from the point of view of a very wide range of conceptions of the good' (Barry 1995, pp. 87-88; Scanlon 1975, pp. 655-659).
The committee noted further that such changes "could be deleterious from the point of view of human beings".
Finally, the fact that LdARL-1 could not complement the yeast arl-1Δ deletion mutant [21] (not shown) reveals that, even for evolutionary conserved pathways such as intracellular traffic, inter-species differences exist, which might hopefully be exploited against deleterious (from the human point of view only) organisms in the future.
The sequencing of multiple individuals of the same species allows the identification of single nucleotide polymorphisms (SNPs) and presents the challenge of distinguishing deleterious from neutral SNPs.
Bayes rule was then used to calculate a posterior probability that the variant was deleterious from the multifactorial LR and the prior probability as determined by sequence alignment.
The functional consequences of missense variants can be difficult to establish, and in estimating associated risks it is important to separate deleterious from neutral variants.
Similar(50)
There is increasing concern about the potential deleterious effects from radiation arising from intervention cardiology due to two reasons: first, cardiac procedure volumes have grown tremendously.
[CBC August 6] Commenters were suspicious about why the government was protecting pharmaceutical companies from legal recourse in the event of deleterious outcomes from the vaccine.
Most people think of inbreeding as bad, but it could be helpful in purging deleterious mutations from a population".
The reason is that sex purges deleterious mutations from the population: sex generates new gene combinations, and thus in each generation it creates some individuals with relatively few deleterious mutations and some with lots.
The chairman of the British Fertility Society's ethics committee has described pre-implantation genetic diagnosis (PDG) as "the best kind of preventative medicine", a means of removing "these horrible deleterious genes from the gene pool".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com