Sentence examples for deleterious form from inspiring English sources

The most deleterious form of DNA damage are DNA double-strand breaks (DSBs), which arise under physiological conditions predominantly from oxidative damage [1], or are caused by genotoxic insults such as ionizing radiation, and are repaired by non-homologous end-joining (NHEJ) and homologous recombination.

Additionally, one can speculate that the association of the 4399 methionine allele with increased risk of disease could also be due to the isoleucine to methionine change in apolipoprotein(a) that may result in a more deleterious form of Lp(a).

Intra-abdominal AT IAATT) is thought to be the most deleterious form of adiposity, and lower-body (or gluteo-femoral) subcutaneous AT (SAT), the least deleterious [ 28- 31].

The most deleterious form of DNA damage is the DNA double-strand break (DSB), which can be formed by free radicals derived from the metabolism, ionizing radiation, or DNA cross-linking agents or which can naturally occur during DNA replication.

To the best of our knowledge, DOB ICL analogue 7 is the only cross-linked DNA that is exclusively transformed into a double-strand break, the most deleterious form of DNA damage.

This uncertainty might arise because WC is a more proximate measure of fat accumulation in the abdominal region, indicating a more deleterious form of obesity, a condition that is highly associated with inflammation, insulin resistance and the future development of diabetes [ 36].

Because this infection is persistent and poorly responsive to antibiotics it is undoubtedly one of the most economically deleterious forms of M. bovis infection [ 13, 15].

DSBs are considered to be among the most deleterious forms of DNA damage because the integrity of both DNA strands is compromised simultaneously.

The debated vascular risk potential of total homocysteine (tHcy), due to failed clinical trials designed on B vitamin supplementation, raises many possible explanations like the higher risk potential of the deleterious, free form of homocysteine (fHcy) or, the unchecked confounding effects of B-vitamins in tHcy-based association studies.

While some of the respective degradation products of particular GS are recognized as health promoting substances for humans, recent studies also show evidence that namely the 1-methoxy-indol-3-ylmethyl GS might be deleterious by forming characteristic DNA adducts.

In fact, studies in mammalian cell lines and transgenic mice indicated that synphilin-1 can form deleterious aggregates as well as cytoprotective aggresomes [19], [22], [23].