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Thus, any disturbances in nutritional or immunological homeostasis can provide deleterious feedback loops that can further enhance health disorders, increase production losses, and decrease the availability of safe and nutritious dairy foods for a growing global population.
Taken all these considerations into account, the AGE-RAGE axis accelerates post-infarct myocardium remodelling, generating a deleterious feedback mechanism.
In addition, the activity of letrozole was correlated with a significant reduction in E -2-) lE -2-, whilevelsondary resistance whilen part related to a deleteriousecondaryk loop resistancein a significant upregulation of testosterone, thereby increasing substrate levels for aromatisation (Doyen et al, 2010).
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We speculated in that work that the higher CpG signal in the 1918 virus could have contributed to its increased lethality via a high cytokine response and that a set of highly expressed innate immune genes may also avoid a CpG signal so as to avoid a deleterious positive feedback loop.
Once 'activated', the endothelium can promote additional congestion through humoral, renal and cardiac mechanisms, resulting in a deleterious positive feedback loop [ 20].
TFEB gene transfer interrupts this deleterious positive feedback loop and results in reduction of calnexin, a molecular chaperone of AAT and a sensor of EOR (Alam et al, 2012; Lawless et al, 2004; Fig 9B), decreased NFκB synthesis and activation (Fig 9B), and normalizes mIL-6 mRNA levels (Fig 9C).
The combination of restricted variation in potentially deleterious directions and feedback between variation and stress, explains how any type of newly-forming random variation can self-organize into emergent physiological adaptations.
There are other deleterious consequences to high-gain feedback for non-minimum phase systems.
Dysregulation of the DPAGT1/canonical Wnt feedback loop has deleterious consequences to cellular homeostasis.
While they are assessing this it seems particularly deleterious to also process external feedback signals, while on a correct response after a correct response they have already established that their response mode has been appropriately reset.
Thus, each feature of baculovirus pathology may be slightly beneficial, neutral, or even deleterious on its own, but feedback from one feature to the other may link the evolution of the two together.
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