Sentence examples for deleterious expression from inspiring English sources

In these gene sets, higher activity is associated with decreased survival, indicating that these gene sets are representative of a deleterious expression signature.

The MLL AF9 fusion protein appears to result in aberrant targeting of SEC to normally silent MLL target genes, causing deleterious expression of these genes.

The loss of repressive heterochromatin with age, a concomitant decline in gene silencing, and the emergence of deleterious gene expression, including expression and mobilization of Ty1 transposable elements, have been demonstrated in replicative aging in yeast [ 3, 24].

This may have a direct impact on translation rate and may also induce metabolic responses deleterious for expression yield [38]. PLS modeling suggests that most of the variation in our dataset can be explained by codons for serine (AGC favored and UCU disfavored), threonine (ACG favored), and leucine (UUG favored).

Moreover, the potential for deleterious gene expression changes resulting from promoter mutations or copy number variation has been addressed in relatively few studies (10, 108– 108).

The purpose of this study was to determine the ability of NCCM to (1) counteract the deleterious gene expression changes induced by IL-1β+FasL in vitro; and (2) inhibit apoptosis of NP cells and determine the signaling pathways involved.

Of course, inbreeding avoidance in this species may also have been selected for the reduction of deleterious recessive gene expression in diploids and inbreeding depression.

For the latter, the ability to knock down deleterious target gene expression has been the primary goal.

This result is mirrored in bacteria where the loxP site is deleterious to protein expression (for example, see Additional File 5F & 5G).

Under this hypothesis, the improved fertility of XYd females is attributed to a reduction of the deleterious Y gene expression as a consequence of the proximal Yp deletions.

In optimizing the human ACHE-S gene sequence, we took a preemptive approach: modifying many molecular features that might have otherwise proven deleterious to the expression of the transgene or to the accumulation of its product.