However, a locus at which fitness variance was ever present owing perhaps to repeated deleterious mutation could experience selection for imprinted expression for prolonged periods through these repeated episodes.
The ratio between the number of beneficial and deleterious mutations experienced by a population of RNA sequences increases with the value of the mutation rate μ at which evolution proceeds.
Psychological processing of early adversity and the individual social support available to the child, may also explain unique variance in the diverse pathways of risk [ 117], including the dysregulation of the HPA axis following deleterious rearing experiences [ 100].
If ethnicity is a partial proxy for exposure to deleterious socioenvironmental experiences, such as the combined effect of social inequality, fragmentation, deprivation and population density, 31 then simultaneously incorporating such factors into our models may improve their predictive validity by ethnicity.
For example, studies of caregivers suggest that only those who feel "strained" experience deleterious health outcomes [ 16].
Non-synonymous SNPs cause a modification of protein sequences that can be benign or deleterious and possibly experience selection.
They may feel uncomfortable taking the initiative to follow up with their doctors even if their symptoms fail to improve or they experience deleterious side effects [ 7].
This suggests that all patients with severe, poorly controlled asthma can experience deleterious effects on the structure and function of their airways, regardless of the duration of disease.
Briefly, an E. coli strain propagated under conditions of weak selection is expected to accumulate deleterious mutations and experience a concomitant decline in fitness compared with its ancestor.
Despite improvements in cancer survival rates (DeSantis et al, 2014), cancer survivors frequently experience deleterious sequela resulting from treatment including impairments in the cardiovascular, pulmonary, neurologic, and musculoskeletal systems (Jones et al, 2009).
