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In contrast, a large fraction of mutations within CNSs must be deleterious enough to be removed by negative selection.
Although the maternal response to ambient drops in employment may not appear deleterious enough to induce fetal loss, the response may elicit clinical signs of distress upon which medical staff may intervene.
If Z/W sex chromosomes evolve from a pair of autosomes that carries very few genes, for instance, the dosage imbalance resulting from W degeneration may not be deleterious enough for selection to favor the evolution of chromosome-wide dosage compensation.
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In Africa, Dr. Jablonski noted, sunlight is so strong that even with dark skins as protection against its deleterious effects, enough light is absorbed to provide high levels of vitamin D. The risk of vitamin D deprivation increased as dark-skinned people moved to temperate zones, then as now.
If enough deleterious passengers are present, their cumulative effects can slow tumor growth, the simulations found.
If enough deleterious passengers accumulate, tumors may become dormant or even shrink, but growth can start up again if new driver mutations are acquired.
It may be that some of these peptides are not functional, but their translation does not produce a large enough deleterious effect for them to be eliminated via selection.
In particular, drugs powerful enough to affect deleterious epigenetic programming will likely trigger side effects leading to shortened lifespan.
The possible explanation for the lack of effect of hypothermia was that 8 min of asphyxia was not long enough to demonstrate deleterious effects of systematic cytokine release.
But since GI is strongly associated with senescence and apoptosis [6], [7], [8], it is unclear how cells tolerate the deleterious effects of GI long enough for these cellular evolutionary steps to occur.
Evolutionary theory predicts that mutational decay is inevitable for small asexual populations, provided deleterious mutation rates are high enough.
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