Sentence examples for deleterious driving from inspiring English sources

Once cells became strong citrate utilizers, the initial gltA mutation became deleterious driving the evolution of a diversity of secondary mutations to compensate for its cost.

An NI lower than one reflects a paucity of non synonymous polymorphism relative to non synonymous divergence, and is indicative of positive selection; an NI greater than one indicates negative selection of deleterious alleles driving divergence between species or balancing selection.

Our work has shown that in the context of ECM PF4 has a deleterious role in driving immune stimulation, including monocyte activation.

As long as one does not recognise that many mutations are truly recessive, one simply cannot venture towards the idea that deleterious ones are driving the absolute requirement for inbreeding, and advantageous ones the initial steps of speciation.

This mechanism is pivotal in driving the deleterious effects of NF- κB activation during lethal ischemia.

However, high level of Rif1 is also deleterious to ESCs by driving malignant transformation of Smad3−/− ESCs.

Our results support a deleterious role of CHOP, driving both ER stress-induced hepatocyte death through the activation of BH3-only proteins and the NLRP3 inflammasome activation in our experimental models.

When we compare the average trend of d N/d S over patristic distances with that of lsrA, we find much higher values for the latter, suggesting that slow purifying selection of slightly deleterious changes is not driving the differences between the two sets.

Purifying selection against these deleterious insertions could be the driving force that governs observed TE distributions [ 15, 19- 23].

Although beneficial mutations are much rarer compared to deleterious mutations, they supply the driving force for adaptive evolution and contribute to survival of populations in tough environments [ 39].

SKAT was found to be more powerful than alternatives when mixtures of deleterious and protective variants were driving the association, as expected.