Sentence examples for deleterious damage from inspiring English sources

The most deleterious damage is a double-strand break (DSB), which is detected and repaired by mechanisms known as non-homologous end-joining (NHEJ) and homologous recombination (HR), which are components of the DNA damage response system.

However, the majority of the children born to these women have no deleterious damage [ 2].

It has been proposed that normal aging results from random deleterious damage to tissue by oxidative stress caused by ROS.

Next, we selected only those variants within coding regions that, passing depth and quality controls, were frameshift, stop gain/loss and non-synonymous amino acid changes predicted to produce deleterious damage in the protein structure (Supplementary Table 1).

The most obvious histological changes, including delayed formation of tubule lumen and decreased tubule diameter as well as the loosely arranged germ cells, were observed in the D450, which showed minor deleterious damages in D150.

MutationTaster, PolyPhen-2 and SIFT algorithms predict the p.R3429S change to be deleterious, probably damaging and damaging respectively.

However, significant amounts of post-negative enrichment residual WBCs, deleterious hypotonic damage and loss of CTCs following hemolysis [11, 12, 29], severely interfere subsequent accurate detection, analysis and primary tumor cell culture of CTCs.

AlkB maintains the integrity of the viral RNA genome by oxidative demethylation through repair of deleterious methylation damage [ 22].

This may include mitigating deleterious oxidative damage to their sperm, and so be directly related to their functional fertility.

A wealth of evidence has demonstrated that microglia, the resident innate immune cells in the brain, can become deleterious and damage neurons.

Negative regulation of TLRs is necessary to control deleterious inflammatory damage, but could provide a means of immune evasion by M. tuberculosis as well.