Sentence examples for deleterious contribution from inspiring English sources

Here, we report on MSCs in HDM‐induced experimental asthma, under the hypothesis of a deleterious contribution to remodeling.

However, the relative deleterious contribution of hypoglycaemia on MACE remains to be fully elucidated, and CAROLINA will also be able to address this.

Recently, we have been able to demonstrate that prion disease is characterized by a massive expansion of the population of microglial cells, generated by local proliferation, and they have a net deleterious contribution to the pathology (Gomez-Nicola et al., 2013).

Implementing a 20-fold dilution of the isolated low MW biofluid fraction prior to injection effectively minimized the deleterious contributions of all three matrices to quantitation.

The net contribution of deleterious background is found to be small, because the reduction in fixation probability for association with the deleterious allele is offset by an enhancement for association with the beneficial allele.

Our results provide evidence for the contribution of deleterious mutations to heterosis via complementation, consistent with the dominance hypothesis.

Furthermore, high observed values of hybrid vigor or heterosis in maize hybrids makes it an excellent system for studying the effects of deleterious mutations and their contribution to heterosis.

In reality, the assumption of neutrality provides an upper limit, as πA values must include a contribution from deleterious mutations, whose fixation is resisted by selection and hence do not contribute to KA.

Sites under moderate selection (f ≳ σ ˜ ) are still partially degraded by interference, and the negative component of fitness flux (i.e., the contribution from deleterious substitutions) is peaked in this regime (see Figure S4 in File S1).

In silico analysis suggested potential pathogenic role for the missense MTO1 mutations identified in our patients, but the yeast model allowed us to experimentally confirm their deleterious effects, dissecting the contribution of single allelic variants and giving an idea of the severity of each mutation.

Successfully predicting cluster transitions will therefore require not only better characterizing the antigenic effects of mutations but also characterizing relative virus fitness, as mediated by differential deleterious mutation loads and contributions of non-antigenic phenotypes, in influenza's HA and other gene segments.