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This failure occurs despite the deleterious consequence of the persistent inflammatory reaction that leads to the decline of lung function and likely to fatal outcome of the disease.
Possible mechanisms of suppression by Hsp70 in RNA-mediated toxicity might involve a misfolded protein response triggered by deleterious consequence of the pathogenic repeat RNA.
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Our data, not only show similar decrease in respiration, but also pointed out the downstream deleterious consequence of this deficit, such as decrease in ATP synthesis rate, proteasomal deficit, and α-synuclein accumulation.
This is not to say that Mr. Johnson fails to raise important questions or to make persuasive arguments about the deleterious consequences of the global American presence.
The calculations confirm the experimental evidence that the main technical limitation is imposed by the SOA carrier lifetime, which must be reduced below the bit period in order to avoid the deleterious consequences of the pattern effect on the switched-out pulses.
First, kinetin as an FD treatment would potentially decrease deleterious consequences of the mutation at the protein level.
It belongs to the group of genetic disorders known as the Repeat Expansion Diseases, in which pathology arises from the deleterious consequences of the inheritance of a tandem repeat array whose repeat number exceeds a critical threshold.
The deleterious consequences of this profound change in the economy were kept hidden for a surprisingly long time.
This post has discussed certain aspects of the logic of the story of expertise and considered two practices that can help short circuit some of the deleterious consequences of that logic.
The deleterious consequence of L-2-hydroxyglutarate dehydrogenase deficiency is the accumulation of L-2-hydroxyglutarate. L-2-hydroxyglutarate induces oxidative stress and inhibits mitochondrial creatine kinase in the cerebellum [ 17, 18].
The installation of additional positive charge also has the deleterious consequence of decreasing ribonucleolytic activity or conformational stability.
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