Sentence examples for deleterious combination from inspiring English sources

We further demonstrated that otherwise harmless minor bacterial aspiration leads to severe pneumonia and bacteriemia after ischemic stroke suggesting that the deleterious combination of stroke-induced immunodeficiency with stroke-facilitated aspiration dramatically increases the susceptibility to infection [39].

Clozapine + quetiapine as dual therapy appears associated with worse than average outcomes (which likely reflects the principle of poorer outcomes in polypharmacy than a deleterious combination of medications).

Our present and previous works suggest that degeneration of long peripheral nerves associated with CMT results from the deleterious combination of different pathomechanisms affecting axonal transport.

A similar effect of the deleterious combination of short sleep duration and insomnia was also observed by Vgontzas et al. [ 7] in a polysomnographic study of insomniacs.

However, it appears that most of human diseases result from deleterious combinations of polymorphic alleles with small effects on the phenotypes and the diseases elicited by single gene defects are fairly rare.

Interchange haplotypes arise as a result of recombinations between L- and M-opsin genes that create unusual, and potentially deleterious, combinations of exon 3 single-nucleotide polymorphisms (SNPs).

Possible paths for evolution of this sequence can be deduced, starting from any single mutation and following the various lines inward, avoiding deleterious combinations.

Genomic evidence suggests that deleterious combinations of maternal NK cell receptor repertoire and fetal HLA-C and HLA-G antigens can shape a strong inhibitory NK phenotype associated with impaired vascular placental remodeling [ 60].

One possibility is that the multilocus genotypes observed in the evolved lines are the result of selection against deleterious combinations of epistatically interacting alleles segregating among the founder genetic backgrounds.

This result suggests to us that perhaps changes in the opa repeat number by contraction or expansion are generally deleterious in combination with other lesions at this locus.

The question is how many of these 120 mutational paths are evolutionarily allowed in the sense that they do not involve deleterious intermediate combinations (i.e. combinations involving strongly decreased fitness).