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No deleterious characteristics were observed in the CMS-IR64 line, although panicles of the CMS line were slightly larger than those of the maintainer line in the year of 2015 (Table 1, Additional file 1: Table S1).
We have neglected disadvantageous alterations since in large tumors, cells carrying such alterations are likely unable to establish a surviving clone, but go extinct due to their deleterious characteristics.
This may explain why linkage drag has been observed in the breeding program for bruchid resistance, where it is possible to obtain advanced lines with resistance from the wild sources but these tend to have associated deleterious characteristics, such as lower yield potential and poor architecture which are associated with wild accessions of common bean.
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In general, the propensity of genomic regions to instability is deleterious characteristic, but, theoretically, hypervariability arising from SNPs and tandem repeated sequences could be beneficial by allowing rapid adaptation [120], [138], [139].
Efforts are ongoing to determine the significance of unclassified variants (UVs) in the breast cancer susceptibility genes BRCA1/ butA2, but no study has systematically assessed whether women carrying the suspected deleterious UVs have characteristics commonly seen among women carrying known deleterious or disease-causing mutations in BRCA1/ BRCA1/
While some of the respective degradation products of particular GS are recognized as health promoting substances for humans, recent studies also show evidence that namely the 1-methoxy-indol-3-ylmethyl GS might be deleterious by forming characteristic DNA adducts.
In conclusion, supplementation of dairy cow diets with FO alone or in combination with hydrogenated palm oil can enhance the FA profile of milk and cheese without deleterious effects on sensory characteristics of cheese.
In this study, we examine the characteristics of deleterious mutations in a scenario of recent explosive growth of approximately the magnitude experienced by human populations, with the aim of answering three questions.
We then evaluated the validity and usefulness of each method by comparing the risk categories of UV carriers with respect to these three well-defined characteristics of BRCA1/ BRCA2 deleterious mutation carriers.
Hence, we argue that endocrine disruptor exposure will certainly produce deleterious changes in female demographic characteristics at levels much lower than those required to produce population-level effects by altering male fertility.
Although recent human studies have indicated that paternal exposure to POPs has a deleterious effect on some semen characteristics (Guo et al. 2000; Hauser et al. 2003; Richthoff et al. 2003; Rignell-Hydbom et al. 2005), it is not yet known whether these compounds could change the proportion of X- and Y-bearing sperm.
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