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While high global efficiency is considered a positive attribute in most networks –so that global communication in the network is optimal [30], [31] –, high global efficiency might be denoting a disturbing structural property in the case of genetic networks, as it indicates that a single gene inactivation leads to a number of particularly strong deleterious cascade effects.
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As a consequence, genes involved in early developmental processes are expected to be under strong negative selection to prevent deleterious cascading effects (Roux and Robinson-Rechavi 2008; Artieri et al. 2009).
The "developmental constraint" hypothesis suggests that genes expressed in early developmental processes are under strong negative selection as a means to avoid mutations that could cause deleterious cascading effects (Raff 1996).
These results do not support the developmental constraint hypothesis and states that genes involved in early developmental processes are under strong negative selection to prevent deleterious cascading effects (Artieri et al. 2009).
This multifaceted deleterious cascade can result in substantial variability in performance even under the same experimental conditions.
Entrapment and activation of platelets in pulmonary capillaries will consequently feed the deleterious cascade of pro-inflammatory and pro-coagulant events in the lung [71, 156, 158, 159 , 165]
This would have a destabilizing cascade effect.
The problem is there's a cascade effect".
That will result in a cascade effect.
It was a cascade effect.
Scientists call this benefit the "Trophic Cascade" effect.
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CEO of Professional Science Editing for Scientists @ prosciediting.com