Sentence examples for deleterious background from inspiring English sources

The need for a very fit mutation (that causes a large antigenic change) to overcome a deleterious background also explains the punctuated nature of antigenic changes.

If A1 is sufficiently beneficial on the island (a > a*), however, it will survive for some time even when arising on the deleterious background.

Figure 2 shows this classification: a target mutation interacts with a deleterious background interfering mutation, with a beneficial background interfering mutation, and with a beneficial future interfering mutation.

If A1 occurs on the beneficial background (B1), the fittest haplotype is formed and invasion is likely unless recombination transfers A1 to the deleterious background (B2).

Competition against fitter residents therefore compromises the increased probability of recombining onto a beneficial background (B1) when A1 initially occurs on the deleterious background (B2).

The dynamics analysed in this paper are complex, because they are shaped by the interplay of beneficial antigenic mutations, deleterious background mutations, and by large fluctuations in population size and absolute fitness caused by the epidemiology of the virus.

In this situation, the fixation of beneficial mutations can be delayed not only by the coexistence of several lines carrying different mutations but also because at high error rate beneficial mutations arise in deleterious backgrounds, thus hampering the action of selection [ 14- 16].

Isolated cleft palate is currently considered to have a multifactorial etiology in which a deleterious genetic background is combined with environmental factors.

This study investigated whether the deleterious effects of background speech can be affected by room acoustic design that decreases speech intelligibility, as measured by the Speech Transmission Index (STI).

Therefore, individuals with heightened memory capabilities may be better able to overcome the deleterious effects of background noise on perception, aiding in the retention, rehearsal and recall of the target speech signal.

These three mutations are also deleterious in the background of polymerase proteins from Aichi/1968 and Brisbane/2007, suggesting that the deleterious effect is intrinsic to NP itself.