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This relatively low cloning efficiency is presumably due to deleterious aspects of the VSG RNAi induction, including the generation of internalised flagella in some of the cells [13].
This overall effect may then translate into a significant compression of the deleterious aspects of human aging with a resultant increase in human life expectancy.
Eqn (1) shown below captures positive aspects of bioenergetic function (reserve capacity and ATP-linked respiration) and contrasts these with potentially deleterious aspects (non-mitochondrial oxygen consumption and proton leak).
Moreover, it is certainly possible that deleterious aspects of aging are prevented by CR in ways that are not reflected by gene expression patterns, and many age-associated expression patterns may indeed reflect favorable compensatory mechanisms rather than pathological processes.
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Compelling people to lie about who they are is perhaps the most pernicious and deleterious aspect of the policy for the individual soldier whose service is predicated upon duty and honor.
SIFT predicted seven of the missense variants to be deleterious.
The ESCRT complexes are central to the recycling of proteins via multivesicular bodies (MVBs) that occur at late endosomes, and defects in this process are deleterious to global aspects of cellular vesicular trafficking (Roxrud et al. 2010).
For instance, if strong positive selection fixes a mutation based on one aspect of the protein's function, but that mutation also has lesser, deleterious effects on other aspects of the protein's function, then natural selection will favor subsequent mutations that ameliorate these antagonistic effects.
By comparing the various analyses it could be safely concluded that except P437L and A379V mutations, all other mutations were potentially deleterious affecting various structural aspects of RING2 domain architecture.
We have also ignored the potential deleterious effects of other aspects of road construction, such as greater access for poachers [6], an important consideration given the fact that the size of the Serengeti protected area substantially buffers it from poaching impacts at present [24], [25].
As well as sleep disorders, shift work is recognised as having a deleterious effect on other aspects of health[ 31] and that females may be more effected than males[ 15] is concerning with their increasing proportion in the medical workforce.
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