Consequently, a careful balance is maintained between the potential benefits of TEs, versus their deleterious aspects, and this control is carried out by the epigenetic regulatory system.
We explored a third approach: activating with the soluble ligand Slit an endothelium-specific, Robo4-dependent signaling pathway that strengthens the vascular barrier, diminishing deleterious aspects of the host's response to the pathogen-induced cytokine storm.
I was happy to learn that victims' support groups were using the book, but I wonder now if it played a part in the spread of the deleterious aspects of the victims'-rights movement, which depends, to a degree, on seeing survivors as a monolithic group.
This relatively low cloning efficiency is presumably due to deleterious aspects of the VSG RNAi induction, including the generation of internalised flagella in some of the cells [13].
This overall effect may then translate into a significant compression of the deleterious aspects of human aging with a resultant increase in human life expectancy.
Eqn (1) shown below captures positive aspects of bioenergetic function (reserve capacity and ATP-linked respiration) and contrasts these with potentially deleterious aspects (non-mitochondrial oxygen consumption and proton leak).
Moreover, it is certainly possible that deleterious aspects of aging are prevented by CR in ways that are not reflected by gene expression patterns, and many age-associated expression patterns may indeed reflect favorable compensatory mechanisms rather than pathological processes.
The ESCRT complexes are central to the recycling of proteins via multivesicular bodies (MVBs) that occur at late endosomes, and defects in this process are deleterious to global aspects of cellular vesicular trafficking (Roxrud et al. 2010).
Ng PC, Henikoff S. Predicting deleterious amino acid substitutions.
In the presence of regulators, most mutations are deleterious.
