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Changes in the selection pressure conferring a higher biological efficacy to a mutation that was previously deleterious are expected to generate hard sweep signatures41.
Gorlov and colleagues recently postulated that SNPs that are potentially deleterious are subjected to weak purifying selection and may represent significant contributors to genetic components of common disease [38].
It is possible that the variants we have identified as potentially deleterious are polymorphisms in one of the ethnic subpopulations.
This somewhat counterintuitive result arises from the fact that low and moderate frequency mutations that are strongly deleterious are overwhelmingly likely to be lost.
Statistical analyses of the distribution of fitness effects reveal that small effects, either beneficial or deleterious, are well described by a Pareto distribution.
The first and more intriguing is that SNPs being classified as deleterious are perhaps more likely to change protein function but not necessarily in a selectively negative way.
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On the contrary, evidence that vaccination was deleterious was held properly to have been excluded.
So what about the science that proves one specific GMO crop is deleterious — is this not science?
2. Therefore, food carrying salmonella (obviously deleterious), is in fact illegal to sell.
Whether this SERPIN activity of antithrombin is beneficial or deleterious is unknown.
Tight glycemic control, nowadays shown to be deleterious, was applied to all patients.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com