Muller [ 17] first described genetic load as the total amount of deleterious mutations in the genome of an organism.
To improve the stable production and use of RAC, the amounts of deleterious impurities present and their effects on the concrete mix should be estimated.
Our aim is to establish the treatment regimens that maximize the effector cell count and minimize the tumor cell burden and the deleterious effects of the total amount of drugs.
The different patterns of NUPT age distribution among plant species might reflect the amount of deleterious NUPTs in each species, or different integration rates among species that account for the amount of recently formed NUPTs.
The GTD-111 superalloy has a multiphase structure consisting of γ matrix, γ′ precipitate, carbide, γ-γ′ eutectic, and a small amount of deleterious phases such as δ, η, σ, and Laves (Sajjadi and Nategh 2001; Sajjadi et al. 2002).
Also, sensible placement of resin inlets and outlets could reduce the amount of deleterious voids, i.e. by promoting resin flow along the fibre direction in the most defect-sensitive off-axis layers.
According to our results, even a minor sex-promoting effect such as a small amount of deleterious mutations may explain the maintenance and emergence of sexual reproduction, since the requirement for an absolute increase of Darwinian fitness is eliminated in this context.
The overall shape of Π is similar to that obtained at the mutation-selection equilibrium: a larger amount of deleterious mutations and a tendency of the distribution to become symmetrical as μ grows.
Utilizing the diethyl ketomalonate-derived N-Boc-oxaziridine 20, a number of primary amines were aminated to N-Boc-hydrazides (123) in good yield without a significant amount of deleterious imine formation (eq 23).
Overall, our data are consistent with a lower amount of deleterious polymorphism in M-type in comparison with F (fig. 6 d and g), that can be explained by a different efficiency of selection on gametes.
