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To investigate whether increased furfural tolerance via deletion of SIZ1 is a strain-specific or general attribute, SIZ1 was also deleted in two other S. cerevisiae strains: HZ848 [ 23] and W303a [ 24].
The 9p21 locus, carrying the p16INK4A gene, was homozygously deleted in two of the metastatic cancers, while this was seen in 12 of the 21 malignant mesotheliomas.
Furthermore, it seems coincidental that the same spacer c3 was deleted in two different evolutionary directions.
It has already been reported that the SAV1 gene is homozygously deleted in two RCC cell lines [ 8].
In our cohort, this gene is deleted in two CLP and four CP patients (Supplementary Tables 3, 6).
Another explanation for the MDM2 protein overexpression is the loss of control by the P14ARF gene which was deleted in two out of three cases revealing MDM2 accumulation.
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In the second group, ten genes were deleted in three of the melanoma samples (see Table S2).
Forty-two sequencesuences ranging from 10 100 nucleotides were identified that were either inserted or deleted in one or more of the three genomes compared (Fig. 2B, Table 3).
Patterns II to V show RDs that are present in the earliest group (group 1) but deleted in one or more other groups.
ApcΔ14/+ mice in which exon 14 of the Apc gene is deleted in one allele spontaneously develop multiple polyps along their intestinal tract [32].
We limited our analysis to regions spanning 3 probe lengths that were either duplicated or deleted in one strain relative to C57BL/6J (B6; the reference strain).
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