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The genes could therefore be passenger deletions and deleted as a consequence of their proximity to CDKN2A.
Whether involved early in the disease or deleted as a consequence of genomic instability and enrolled as a partner in the progression of the malignant phenotype it will be important to establish the role of genes at fragile sites in relation to specific carcinogen exposure and disease behavior.
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The higher frequency of LCE3C_LCE3B-del found in most of non-Sub-Saharan African populations suggests the fixation of the deleted allele as a consequence of the genetic drift that occurred during the exit from Africa.
Since the B. aphidicola genomes evolved mainly by deleting genes from an E. coli-like ancestral genome [ 45], this analysis, together with the previous ones, strongly suggest that the process is still ongoing: different Buchnera strains are independently deleting genes as a consequence of the selective pressure experienced in specific hosts.
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