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[H]-thymidine incorporation reached its peak at 32 hours after activation in control experiments (plated on plastic), and cells plated on collagen-coated plates did not show any delayed peak, demonstrating that the effect of collagen was not delaying the progression of cell cycle but blocking DNA synthesis.
He said the agency had sympathy for the view that delaying the progression of life-threatening disease "may be a direct clinical benefit in itself".
Two other studies presented at the conference show that the widely used cancer drug Avastin is effective in delaying the progression of ovarian cancer.
"The provision is that the drug's benefits have to be clinically meaningful — and it doesn't mean delaying the progression of the tumor by two days — so you're not approving iffy drugs".
The Medical Therapy of Prostatic Symptoms (MTOPS) trial is a multicenter, randomized, placebo-controlled, double-masked clinical trial designed to evaluate the long-term efficacy of the alpha-blocker doxazosin and the 5-alpha-reductase inhibitor finasteride, whether taken as a monotherapy or in combination, in preventing or delaying the progression of BPH.
The biggest drawback of the study, critics said, is that the real gain from the drugs, and the real savings in health care costs, would come from delaying the progression of the disease, allowing people to go longer before, say, needing a wheelchair.
Their real effect is keeping cancer under control for the long term, delaying the progression of the disease.
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"It does have the potential to seriously delay the progression of the disease, though.
It's meant to delay the progression by three to six months or so.
However, the abovementioned treatments can only delay the progression of articular cartilage damage but can not solve the problem fundamentally.
Treatments aim to delay the progression of swelling and to improve patients' quality of life (QOL).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com