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We found that PDE10A inhibition significantly delayed the induction of in-life neurological impairment.
Additionally, significantly more L-NAME treated ookinetes were undergoing apoptosis at 20 h than 18 h post-infection (P<0.001) but this increase was not detected in the control treatments, suggesting that inhibition of NOS activity had delayed the induction of apoptosis (Figure 3A).
However, autophagy has delayed the induction of apoptosis in HCT116 p53 −/− cells.
Dapsone delayed the induction of aging and was shown to suppress mitochondrial ROS as well as mRNA of NADPH-oxidase.
Overexpression of PCGEM1 in tumor cells inhibited PARP (poly-ADP-ribose-polymerase) cleavage and delayed the induction of p53 and p21 [ 52], resulting in increased chemoresistance.
Our study showed that PIAS4 siRNA decreased or delayed the induction of HIF1 α expression, and suppressed phosphorylation levels of STAT3.
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Our study suggests that intracellular bioactivation of promutagens may not delay the induction of micronuclei in the present model, and 1-methylpyrene and 1-hydroxymethylpyrene may be activated to mitosis-arresting metabolites.
For the Rock Hall, that might be a risk: four years ago hundreds of members of the Kiss Army - a k a fans - protested at the Hall of Fame and Museum in Cleveland, with slogans like "Thou Shalt Not Delay the Induction of Kiss" and, perhaps most frighteningly, Kiss costumes.
Both the presence of constitutively expressed Pax3 or Pax7, and inhibition of Pax3 and Pax7 transcriptional targets using the dominant-negative constructs, delay the induction of myogenin.
Depending upon increasing or decreasing the availability of ACh at the NMJ, any chemical treatment or mutation, hastens or delays the induction of this paralytic effect.
However, since both Pax3 and Pax7 can delay the induction of myogenin expression, and so differentiation, it is possible that where inhibitory effects of Pax3 on myogenic differentiation have been reported, the time of analyses might have fallen within this period of pronounced delay [22], [23].
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