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This delayed restoring force speeds up Muller's ratchet.
We have used these insights in the coupling between n0, the mean fitness, and the resulting delayed restoring force on fluctuations of n0 to approximate the rate of Muller's ratchet.
Fluctuations in the size of this class propagate to the mean, which in turn generates a delayed restoring force opposing the fluctuation.
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In MMTV-PyMT/CSF-1-/ mice, tumor progression and metastasis are significantly delayed but restored on the overexpression of CSF-1 in the mammary gland [ 48, 50].
The loss of these genes delayed reproduction, and restoring either gene back to worms hurried them into adulthood.
The global sense of well-being and symptom improvements at end organs would occur, but as an indirect and possibly temporally delayed, outcome of restoring allostatic network function to normal [ 136].
More recently, in a rat model of sepsis, Terashima et al. [ 69] demonstrated that FO-enriched PN may regulate neutrophil functions, restoring delayed apoptosis, which was associated with an increase in leukotriene B5 (LTB5) production from peritoneal neutrophils.
WASHINGTON — Airport operators said Wednesday that a prolonged delay in restoring federal funds for airport construction projects would eventually endanger airport safety and lead to more passenger delays.
Delays in restoring electricity and telecommunications have kept businesses closed.
The upshot: yet more delays in restoring electricity in this city, weeks after the war ended.
The delay in restoring full power is figuring in the debate over Ontario's energy policies.
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