Sentence examples for delayed replication of from inspiring English sources
These results suggested that the silencing of RBM24 stimulated the initial translation of HCV proteins but inhibited and delayed replication of HCV genome.
Rather, we propose that the epigenetic instability arises because of delayed replication of structures that would normally be promptly resolved.
This has been reported as sufficient to result in many of the cytarabine-associated phenotypes, including the delayed replication of human leukaemic cells in vitro, and oxidative stress.
In addition, the delayed replication of several neuronal-associated genes in XEN cells relative to ES (for example Otx2, Sox1 and Sox2), infers a change in chromatin status and the loss of promoter acetylation.
We have suggested that a key consequence of the delayed replication of the +3.5 G4 motif in rev1 cells is the uncoupling of the helicase and leading strand polymerase to create of post-replicative gap.
DNA replication and DSB formation are coordinated at the local level, because delayed replication of a single chromosome arm delays DSB formation on that arm (Borde et al., 2000).
Thus, CTSs within the H19 ICR domain appear to influence the timing by delaying replication of the maternally inherited Igf2/H19 domain (Bergstrom et al. 2007).
Altogether these observations clearly indicate that a common feature of CFS is delayed replication, substantiating the hypothesis that CFS are regions intrinsically difficult to replicate.
In particular, this is presumably the case for origins that show delayed replication due to the chromatin state of the chromosomes [27] or to the Cdk1-Clb5 activity [43], [44].
It is hypothesized that breaks at fragile sites may serve as signatures of stalled or delayed replication in tumor cells, aggravated by deficiencies in the S-phase and G2/M checkpoints or associated repair genes during tumorigenesis [ 37, 38].
It is generally agreed that fragile sites comprise regions of high DNA flexibility and display delayed replication [12], [13].
