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As shown in Figure 6A, although in WT mice new myotube formation in TA muscle was observed at 7 days, Tg mice showed delayed regeneration with fewer regenerating fibers.
delayed regeneration value.
In the regeneration tests, a 120-h delayed regeneration value (Pd120h) was calculated for each concentration.
To obtain this value, the number of delayed regeneration planarians in the control was subtracted from the treated number.
The delayed regeneration of P. decumbens cell wall under simulated microgravity was likely caused by the inhibition of polysaccharide synthesis.
However, telomere shortening was associated with delayed regeneration after acute pancreatitis apparently involving p53- and p21-independent mechanisms.
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As these agents may behave as foreign bodies, inducing inflammation and delaying regeneration, they could enhance the risk of epidural fibrosis.
For instance, the critical contribution of non-parenchymal cells has been demonstrated using animals where Kupffer cells have been depleted, thereby significantly delaying regeneration following hepatectomy [ 14].
Mice lacking NF-L, another binding partner for Ndel1 differentially regulated during axon regeneration, exhibit delayed axon regeneration following sciatic nerve crush [32].
It is conceivable that impaired acinar cell regeneration led to delayed pancreas regeneration and a prolonged persistence of metaplastic tissue in the pancreata of G3 mTerc−/− mice compared to mTerc+/+ mice.
Indeed, data from several models of muscle injury (hindlimb ischemia, freeze-injury, unloading/reloading sequences, and myotoxic agent injections) indicate that impairment of macrophage recruitment in injured muscle results in delayed tissue regeneration in terms of appearance of regenerating centronucleated myofibers and persistence of intramuscular adipocytes and fibrosis [ 55].
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