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In addition, upregulation of tenascin-C and p-EGFR was observed in the recurrent tumors and inhibiting p-EGFR signaling significantly delayed recurrence without affecting initial tumor regression.
In order to investigate the mechanism that led to the delayed recurrence, we collected the residual tissue after treatment as well as recurrent tumors from both groups and performed histological analysis.
However, a delayed recurrence of symptomatic vasospasm is infrequent.
51 An increase in the number of mature dendritic cells in the peripheral blood was associated with remission or delayed recurrence.
Although we cannot speculate as to the molecular mechanisms relating to these trends, they reflect clinical experience with delayed recurrence following endocrine therapy.
Patients immunized in our trial and who had developed IgM and IgG antibodies appeared to have benefit, with significantly delayed recurrence.
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This theory is supported by Demicheli's persistent delayed peak in recurrence despite chemotherapy, as well as delayed recurrences seen in the more recent literature [ 1, 2, 14].
No delayed recurrences were observed.
Numerous publications describe clinical times to disease recurrence or death, using mathematical approaches to infer mechanisms responsible for delayed recurrences.
Moreover, as delayed recurrences as well as periods of tumor dormancy are more evident in the node negative patient [ 23, 24], we analyzed this group of patients separately.
23, 24 Patient follow-up is necessary after treatment because delayed recurrences and an absence of histological cure has been reported in lesions that are in full clinical remission.
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