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Paclitaxel was reduced in three patients (six cycles) due to neurotoxicity; 5-FU was reduced/omitted in four (12 courses) due to gastrointestinal toxicity (diarrhoea, mucositis), in one patient (two courses) due to skin toxicity and in seven (12 courses) due to central venous access problems (delayed positioning in five patients, catheter infection or thrombosis in two).
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The design comprises delayed position and position velocity signals with the known and unknown structures of the master and slave manipulator dynamics.
During ground-based rendezvous, stability problems induced by delayed position measurements can be compensated by using a specially adapted navigation filter.
The device is obtained by a similar delayed position feedback mechanism as in the case of DR, but this feedback imparts two (instead of one) distinct and fixed resonance frequencies.
An exciting conclusion is drawn, that there is an inherent dual frequency of resonance for each given mass-spring-damper trio which is brought to dominance by a particular delayed position feedback.
This paper presents a systematic approach to stabilizing a kind of linear undamped systems of multiple degrees of freedom by using both position and delayed position feedbacks, namely, PDP feedbacks for short.
Such a control structure includes state controllers (placed on the local and remote sites) and a time-delay compensation, which modifies the delayed position command generated by the human operator using the force that he feels in such a delayed moment and the current force between the slave and the remote environment.
The first step is to move all the eigenvalues of the system on the imaginary axis of the complex plane by using a position feedback, and the second step is to drag all the eigenvalues of the system to the left half open complex plane through the use of a delayed position feedback, which can be determined on the basis of sensitivity analysis of eigenvalues.
The local and remote platform is coupled by delaying position, position-velocity and impedance reflection characteristics of the input interaction forces between human master and slave environment.
Some of these defensive positions were only lightly defended and intended more as delaying positions than true defensive lines designed to stop an enemy attack.
Further east, delaying positions were constructed in the immediate tactical zones along the Albert Canal, which joined with the defences of the Meuse west of Maastricht.
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