Your English writing platform
Discover LudwigSuggestions(1)
Exact(3)
Electrophysiologically, in vivo grafted VMN-Wnt5a DA neurons were remarkably similar to those grafted in vitro, displaying mature functional properties and no delayed inward rectification (Fig. 2I L, Text S1; Table S1).
Since grafted stem cell-derived DA neurons lacking "sag" have been shown to ameliorate functional deficits in 6-OHDA lesioned animals [7], the significance of the delayed inward rectifier currents for the therapeutic action of grafted DAergic neurons is unclear.
However, the characteristic delayed inward rectifying "sag" was not observed in any of the grafted DA neurons [27].
Similar(57)
These depolarizing stimuli, however, did not elicit astrocytic [Ca2+]i transients, but in four of six recorded pairs, astrocyte depolarization was followed by a delayed slow inward current in the recorded TC neuron (Fig. 9A and B).
Our numerical simulation demonstrates that the DS phenotype can be reproduced by changing the conductance of the delayed rectifier, inward rectifier, HCN, M-type and A-type channels.
The depression of calcium uptake activity delays the inward calcium current, thus prolonging the action potential duration resulting in myocardial conduction delay.
However, further voltage clamp studies will be needed to characterize the effect of U50488 on the delayed rectifier or inward rectifier potassium current.
Because the delayed rectifier and inward rectifier potassium channels play a key role during repolarization of action potential in guinea pig [ 28– 30], the shortening of action potential may be related to these channels being affected by U50488.
Electrophysiological studies of microglia in cell culture and tissue slices have demonstrated that microglia express several types of Kv channels including inward and delayed rectifier Kv channels and the expression levels of these Kv channels in microglia undergo dramatic changes during the process of activation.
13 Dronedarone has demonstrated an inhibitory effect on the following potassium channels: rapid delayed rectifier, slow delayed rectifier, acetylcholine-activated, inward rectifier, and sustained currents.
Alternatively, altered Na handling due to increased late Na current can contribute to cytosolic Ca overload through the Na/Ca exchanger and/or thus may lead to a transient inward current with delayed afterdepolarizations.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com