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Chronically elevated levels of the stress hormone cortisol are related to lower growth hormone levels in children, possibly resulting in delayed, impaired and even stunted growth [ 35].
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In humans, genetic disruption of the neurotrophin receptor TrkB (Yeo et al., 2004) and in its ligand BDNF (Gray et al., 2006) cause severe hyperphagia and obesity, developmental delay, impaired short-term memory, and unusually hyperactive behavior.
The synergistic effects of two model PAHs, an aryl hydrocarbon receptor (AHR) agonist (β-naphthoflavone) and a cytochrome P4501A (CYP1A) inhibitor (α-naphthoflavone), caused significant developmental delays, impaired cardiac function, severe morphological alterations and failure to hatch, leading to the deaths of reference embryos; resistant embryos were mostly unaffected.
Diabetic individuals show delayed and impaired wound healing.
Approximately 7.9 million fractures occur annually in the United States with 5 10% of these resulting in delayed or impaired healing.
Second, as the SAPSII-high group tends to be older, the delayed and impaired immune response might have been related to age rather than severity.
In developing miro1/miro2 embryo sacs, fusion of polar nuclei was further delayed or impaired compared to miro1 plants.
These results indicated that knockdown of Eef1a2 expression delayed or impaired IL-6-induced activation of both the STAT3 and AKT signaling pathways.
VP abilities improve during infancy and childhood in normal development [6], [7], [8], [9], [10] but development may be delayed or impaired in neurogenetic disorders such as Williams syndrome [11], [12], [13], [14].
We then removed MyD88 in silico by shutting down the TLR4→MyD88 reaction (Reaction 1 in supplementary Table SI) and simulated delayed and impaired activation of p38, ERK, JNK, NF-κB, Tnf and Socs3 (supplementary Figure S1 and Figure 1D,E, red), which matches experimental observations with MyD88-deficient macrophages upto 60 min (Figure 1B,C, red and [3], [7]).
TNFα-induced IKK phosphorylation and activity were severely delayed and impaired when TfR1 was depleted.
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