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Thus, similar to the hygiene hypothesis in allergy and asthma, a delayed exposure to common pathogens in developed societies may lead to abnormal or dysregulated immune responses that promote growth of the leukemic clone [12].
Childhood B-cell precursor acute lymphoblastic leukemia (BCP ALL) is usually initiated in utero and is thought to progress to overt leukemia under the influence of delayed exposure to a common infection.
In general, increased incorporation of DH in the intermediate layer or of XG in the outer layers reduced the drug release because of restricted and delayed exposure to the dissolution medium or formation of a stronger diffusion barrier, respectively.
The present study was designed to determine whether delayed exposure to sevoflurane could induce ischemic tolerance and if this effect was dependent on increasing phosphorylated Akt-Ser473 and GSK-3β-Ser9 expressinn in the mitochondria, via a mechanism involving the PI3K/Akt pathway.
This difference in body weight patterns is most likely due to the irradiation and delayed exposure time to diet which results in milder weight gain as reported in many previous studies [34].
Finally, the increased risk of MS, either with delayed exposure to EBV [30], [31], [35], [81] or following symptomatic mononucleosis [32], [34], [35], [38], strongly suggests that the association between MS and this particular pathogen is genuine.
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This step decreases the number of parameters to be pooled in the second stage, offering a method to meta-analyse estimates from richly parameterized non-linear and delayed exposure-response relationships.
The vital status was ascertained for the period 1960 2002 through a request to the municipalities' registry office; the workers hired after 1993 were excluded to allow a minimum 10 years latency time for delayed exposures effects [ 19].
Release of immunoreactive basic fibroblast growth factor (bFGF) from the composites increased up to 5-fold following ADV and delayed release was achieved by delaying exposure to ultrasound.
This randomized, unmasked feasibility study is evaluating the effect of delaying exposure to gluten until the age of 1 year.
However, the decision to delay exposure to the training programme itself facilitated a lack of preconceptions on either the utility or efficacy of the programme with stroke survivors.
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