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Fingolimod reduced relapses by 54 %, and delayed disability progression, lesion activity, and brain volume loss versus placebo over 2 years in the pivotal, randomized FREEDOMS clinical trial (Table 2) [ 114].
While clinical trials have shown that teriflunomide reduced relapses and delayed disability progression compared with placebo [ 60, 61], a head-to-head study versus IFN beta-1a SC (TENERE; ClinicalTrials.gov #NCT00883337) has also shown no superiority of daily teriflunomide versus high-frequency IFN in patients with MS [ 62].
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Findings suggest that more recent cohorts are more likely to forego or delay disability over a decade rather than experience prolonged periods of mild to severe disablement.
In other words, instead of delaying disease, they delay disability.
Examining whether early aggressive therapy can prevent or delay disability in people with multiple sclerosis: the TREAT-MS study.
Because of the complexity and rapidly progressive nature of severe AS, a geriatrician should be involved because of the need for a comprehensive geriatric patient assessment that may ameliorate or delay disability, cognitive dysfunction or nutritional status and their impact on clinical outcomes.
In the public health effort to delay disability in old age, total daily physical activity may be an important factor.
When this happens we have to send the CVI back with a covering letter which delays disability registration and can delay services for the patient.
The development and implementation of effective interventions to prevent or delay disability in older people is an important public health priority.
This sample was drawn from that of a larger randomised control trial testing the efficacy of Tai Chi in delaying disability onset (Exercise for Independent Living trial- ExIL).
Although malnutrition and physical frailty markers are considered strong indicators for functional decline in the elderly [ 31, 32], the question is whether targeting underlying mechanisms of frailty can prevent or delay disability.
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CEO of Professional Science Editing for Scientists @ prosciediting.com