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Following PMR, these patients were reviewed to assess the need for delayed conversion to an autologous flap with exchange of the tissue expander for definitive prosthesis, particularly if the aesthetic outcome was significantly compromised.
Early IFN beta-1b therapy significantly delayed conversion to MS, irrespective of the endpoint used; benefits were seen after only a few months with the McDonald criteria [ 26], and conversion to CDMS according to the Poser criteria [ 27] was delayed by ~1 year [ 5, 6].
The number of cases in this group is small; the single delayed conversion to an intramedullary nail had no complications.
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Eventually, early intervention in prodromal stages to delay conversion to pathological aging is the ultimate goal.
More study is needed to understand the extent to which cognitive interventions are effective to delay conversion to dementia.
On the other hand, those with many white matter lesions were frequently initiated in immunomodulatory treatment, presumably delaying conversion to multiple sclerosis.
Cognitive interventions for older persons that may diminish the burden of cognitive problems and could delay conversion to dementia are of great importance.
In that case it is important to intervene in an early stage to prevent or delay conversion to dementia and to minimize the impact of these objective or perceived cognitive problems [ 5, 7].
However, the exact interpretation and stability of these changes remain unclear just like to what extent cognitive interventions are effective to reach the ultimate goal: to delay conversion to or prevent progression of dementia.
The work by Y. Os et al. from Maastricht University (Netherlands) focuses on cognitive intervention strategies and shows that these strategies change the brain activation process even in cognitively impaired persons; whether such cognitive interventions may be effective to delay conversion to dementia remains an open question.
In the study by Burman et al [21], strains belonging to the East Asian lineage were associated with increased risk of relapse and failure, but not with delayed conversion at week-8 cultures.
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CEO of Professional Science Editing for Scientists @ prosciediting.com