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Hyperthermia was performed 24 h later at 42.5 degrees C. Growth delay to reaching 3 times initial tumor volume was chosen as the biologic endpoint.
In clinical trials, outcomes may be measured as: the mean difference in the total score on a given scale between active treatment and comparator groups; the delay to reaching specific milestones; or the percentage of 'responders' to treatment compared with a comparator treatment group or placebo.
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This paper also develops an optimal delay determination method for selecting the delay to reach the best performance.
This entailed a delay to reach the slaughter BW of 1.8±0.43 d per g Lys restriction/kg of diet which was related to worse FCR by 0.034±0.0095 and to an increase of fat thickness at GM muscle of 0.51±0.168 mm.
The resistance to heparin was carefully checked by the delay to reach an adequate aPTT (activated partial thrombin time) (between two to three times of control).
A long delay to reach therapeutic anticoagulation may precipitate to death or might indicate decompressive craniectomy, especially in the presence of intracranial hematoma.
For 600 kBq/kg 227Th-trastuzumab, all tumors responded to the treatment (Figure 3f) and the average growth delay to reach a tumor volume of 500 mm3 was 45 days (Table 1).
Hence, the optimal W PBO for a given value of M is the smallest value of W PBO that yields the highest P S. The optimal W PBO here is effective for a delay-tolerant application since it might introduce an additional average access delay to reach the highest P S. For an optimal value of W PBO, the corresponding N PTmax can then be determined based on the W PBO using (1).
"When Congress returns, I urge them to keep working without drama, without delay, to reach an agreement that extends this tax cut, as well as unemployment insurance, through all of 2012," the president said during brief remarks at the White House.
These findings may explain the delay to reach the G2/M peak observed in both normal and transformed cells released in low or complete absence of glutamine (Figure 6 and 7).
Transformed cells, released in 4 mM glutamine plus rapamycin or 0 mM glutamine, showed a slower exit from G1 arrest and a 4 hours delay to reach the S-phase and the G2+M peaks (panel D and F, peaks indicated by asterisks) as compared to 4 mM sample and 0 mM plus dNTPs.
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