By increasing energy depots in the muscle prior to slaughter, the anaerobic production of lactate post mortem may be delayed, thereby delaying of decline in pH and reducing drip loss.
Use of calcium-channel blockers, angiotensin-converting enzyme inhibitors, digoxin, or nitrates did not affect the rate of functional decline.In this population-based study of individuals with incident AD, use of statins and beta-blockers was associated with delay of functional decline.
Thus, if the progression of white matter changes could be reduced via altering modifiable risk factors it might contribute to the prevention or delay of cognitive decline.
One high-quality study applied a physical activity program with moderate to high intensity and showed a significant delay of ADL decline only after 12 months duration, but not after 6 months [ 25].
This review specifically focusses on the evidence in humans from epidemiological, dietary intervention, and supplementation studies, which supports the role of long chain omega-3 fatty acids in the prevention or delay of cognitive decline in AD in its early stages.
Preventing weight loss may help delay this process of decline.
Many population-based studies have demonstrated a beneficial effect of exercise on the delaying of cognitive decline [ 11, 45].
In overweight subjects, preventing weight gain may also be important in delaying this process of decline.
Another question is whether earlier use of insulin can, by "resting" β-cells, delay the decline of their function as was suggested by initial analysis of progression from impaired fasting glucose or impaired glucose tolerance to overt diabetes in ORIGIN (4).
There was a significant delay in the rate of decline from acrophase to nadir for cortisol levels in patients with FMS (P<.01).
