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Finally, there was one patient who experienced DLT in level 2. In level 3, three patients were enrolled; one experienced DLT due to febrile neutropenia and two experienced DLT due to delay of administering docetaxel.
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In a diagnostic clinic, where results are often required within days of administering diagnostic tests, some existing technologies can delay the return of clinical results.
With the longer delay to administer appropriate antibiotic, a trend of higher mortality rates was observed.
In the first sensitivity analysis, we assessed the primary exposure of delay in administering epinephrine after chest compressions had begun.
Indeed, each hour of delay in administering effective antibiotics for septic shock is associated with measurably increased mortality [ 6, 21- 25].
American Society of Anesthesiologists ASAA) clinical practice guideline recommendation concerning spinal anesthesia for cesarean delivery states: "Although fluid preloading reduces the frequency of maternal hypotension, initiation of spinal anesthesia should not be delayed to administer fixed volume of intravenous fluid [ 11]".
Delayed diagnosis of histoplasmosis increases the likelihood of delays in administering effective antifungal therapy.
No DLT was noted in the next two patients recruited to dose level 2. The first patient treated at dose level 3 had grade 3 thrombocytopaenia after cycle 1 resulting in a 2-week delay in administering cycle 2 of therapy but experienced no other DLT.
In addition, the early identification of patients who will really benefit from antifungal therapy (AFT) remains a matter of concern, since any delay in administering an appropriate antifungal drug is likely to worsen the outcome of such patients [ 4- 8].
Florida that "a growing number of courts outside the United States... have held that lengthy delay in administering a lawful death penalty renders ultimate execution inhuman, degrading or unusually cruel".
1 This delay in administering adrenaline may lead to increased morbidity and also increases the risk of fatality.
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