Delayed onset of death occurred in rodents exposed to chlorine by mucus plugs and overshooting fibro-proliferative inflammation and regeneration [116], while delayed lethality did not occur in more recent studies of phosgene in rats [38].
Some alleles of whd affect both delay and lethality, whereas others affect only lethality.
Larval ingestion of Pf-5 and SBW25 produced several larval and adult phenotypes in addition to developmental delay and/or lethality.
Together, these results indicate that hlyA has a specific role in eliciting intestinal vacuolation during V. cholerae infection in C. elegans that may represent a crucial step in pathogenesis leading to developmental delay and lethality.
Here, we present data showing that the developmental delay and lethality associated with DAE are largely due to oxidative stress.
Conventional gene-targeting of pten in all mouse tissues (pten−/− mice) results in developmental delay and lethality at embryonic days 6.5 8.5 due to a failure in chorio-allantoic fusion (Kishimoto et al, 2003).
Ablation of the IPCs during larval development leads to reduced body size, developmental delay and lethality, phenotypes that are similar to what is observed with mutants in the InR (Broughton et al., 2005; Chen et al., 1996; Ikeya et al., 2002; Rulifson et al., 2002).
It is possible, given the variety of ways in which ethanol can induce oxidative stress, that developmental delay and lethality are due to different "types" of oxidative stress, or that different mechanisms predominate depending on developmental stage and/or tissue type.
Accumulated ambient UVB exposure during early stages of development can cause developmental delays and/or lethality that will affect recruitment to adult populations [10], [11], [12].
In line with this, a Brca1 truncation mutant lacking the second BRCT repeat shows a delayed embryonic lethality when compared with Brca1-null mutants (Hohenstein et al, 2001).
