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Moreover, the absence of effective, rapid point-of-care diagnostics leaves doctors to treat "empirically," relying on informed guesswork about which medicines a patient's infection might respond to — often in situations where a few hours' delay in commencing effective treatment can mean the difference between life and death.
In addition, we only looked at the delay in commencing the first definitive systemic therapy treatment.
A considerable delay in commencing EN in each nutrient feeding route occurred in the RCT from India [ 14], resulting in a potential selection bias.
Monitoring was started within 8 hours of intubation for >75%% of participants.> -wrap-foot> aOne patient in each group had a long delay in commencing Responsiveness Index (RI) monitoring by clinical staff after randomisation.
This can prevent the delay in commencing treatment that is otherwise experienced while waiting for the arrival of emergency personnel, reducing the need for hospitalization and providing reassurance for patients and their caregivers.
Some studies reported delay in commencing treatment of MDR-TB patients, although diagnostic and treatment initiation delays were frequently reported in these studies; the context and definition of delays were variable [ 8– 14].
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Disadvantages include the need for ovarian stimulation (and subsequent high estradiol levels), cost (variable), possible delays in commencing adjuvant treatment (Lee et al., 2006) and the risk of cancelled cycles.
In some cases, this could lead to delays in diagnosis, resulting in increased anxiety among patients and further postponement in commencing definitive treatment.
Delay in diagnosis and management, especially in commencing antibiotics have also been found to correlate with poor outcomes [ 23].
At 72 hours delay before commencing ADAC treatment, the threshold shifts were similar to nontreated animals.
We suggest that this, coupled to a typical delay in onset between commencing sorafenib and hepatic failure, would support an immune mediated process.
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